The Complex Biochemistry of the Autism-GI Connection

From the “I’m not at all surprised at this,” section, researchers have found GI problems in autistic people to be genetically linked to their autism. Now, while I have connected autism to leaky gut through glutamine, these researchers have connected autism and the GI tract through serotonin.

Serotonin is derived from tryptophan, an amino acid, and serotonin, oxytocin, and vasopressin, three brain hormones that affect social behavior, are all activated by vitamin D hormone. There is recent research that shows a connection between this system and autism. It is perhaps not surprising that a system involving neurotransmitters plays a role in certain kinds of autism.

It turns out that low vitamin D affects the levels of these hormones. And, coincidentally, when I went to see the doctor a few years ago for a checkup, he told me I had low vitamin D.

Consider this fact from Mercola: “vitamin D is a fat-soluble vitamin, which means if you have a gastrointestinal condition that affects your ability to absorb fat, you may have lower absorption of fat-soluble vitamins like vitamin D as well. This includes gut conditions like Crohn’s, celiac and non-celiac gluten sensitivity, and inflammatory bowel disease.”

All of those gut conditions are caused by leaky gut. Leaky gut is caused by too much glutamate relative to glutamine. This in turn affects the ability to absorb vitamin D, which in turn affects the production of the above neurotransmitters. Including serotonin, which in turn affects the gut. 

I have vitamin D and glutamine tablets in my cupboard. It looks like I’ll be taking them every day from now on. And asking Daniel’s doctor about whether or not Daniel has a vitamin D deficiency. Because Daniel has severe GI problems.

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